Machine learning identifies natural compound to treat lung disease
A new study published in Engineering has combined machine learning (ML) and experimental validation to identify dihydromyricetin (DHM), a natural flavonoid, as a potent inhibitor of the TGF-β/ALK5...
View ArticleNew study solves lung transplant rejection mystery
More than 50% of lung-transplant recipients experience a rejection of their new lung within five years of receiving it, yet the reason why this is such a prevalent complication has remained a medical...
View ArticleTargeting TGF-β signaling as a strategy to treat liver fibrosis
Liver fibrosis, a pathological scarring process resulting from chronic liver injury, represents a significant global health burden due to its potential progression to cirrhosis and hepatocellular...
View ArticleQureight's synthetic study arms validate clinical efficacy in pioneering rare...
Qureight, a deep-learning analytics company accelerating drug development through AI-powered data curation, today announced that its digitally-twinned synthetic control arm has been used in a...
View ArticleAI-designed drug shows early promise for lung fibrosis patients in clinical...
Researchers report that rentosertib, an AI-discovered TNIK inhibitor, showed promising safety and potential to improve lung function in patients with idiopathic pulmonary fibrosis in a 12-week phase 2a...
View ArticleGlobal clinical trial tests two anti-inflammatory drugs for long COVID
Spanning four continents and enrolling hundreds of people, a new clinical trial will test the effectiveness of two anti-inflammatory medicines as potential treatments for long COVID, scientists from...
View ArticleAdvancing pulmonary fibrosis treatment through targeted drug delivery
Announcing a new article publication for BIO Integration journal. Pulmonary fibrosis (PF) is a progressive interstitial lung disease characterized by excessive extracellular matrix deposition and...
View ArticleBlocking Piezo2 may offer a new therapeutic approach for pulmonary fibrotic...
Researchers have found a potential new way to slow the progression of lung fibrosis and other fibrotic diseases by inhibiting the expression or function of Piezo2, a receptor that senses mechanical...
View ArticleIn silico docking of clinically approved drugs against the SARS-CoV-2...
Announcing a new article publication for BIO Integration journal. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in China in December 2019, rapidly spread worldwide,...
View ArticleNew study offers hope for extending ovarian healthspan and function
A woman's ovaries are like a factory where eggs grow and produce hormones that regulate everything from menstruation and pregnancy to bone density and mood.
View ArticleU-M study reveals potential pathway to reverse lung fibrosis
The most common type of lung fibrosis -; scarring of the lungs -- is idiopathic, meaning of unknown cause.
View ArticleUVA scientists develop new approach to machine learning for identifying heart...
University of Virginia scientists have developed a new approach to machine learning – a form of artificial intelligence – to identify drugs that help minimize harmful scarring after a heart attack or...
View ArticleHuman senescent fibroblasts trigger fibrogenic reaction in the lungs of...
A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Human senescent fibroblasts...
View Article3D-printed vaginal ovules offer promising treatment for endometriosis
3D-printed vaginal ovules offer controlled release and targeted treatment, showing promise for conditions like endometriosis.
View ArticleUnderstanding post-COVID interstitial lung disease: Causes, treatment options
After being hospitalized for three months with COVID-19 and double pneumonia in 2020, Houston police officer Hito Bazan awoke one morning to discover that he couldn't talk, eat, walk, or most...
View Article3D cell culture system tests how inhibiting fibroblast activities can help...
Fibroblasts build and maintain the extracellular matrix, or physical scaffolding for cells, in the connective tissues within the body.
View ArticleAnti-fibrotics found to be safe, effective for interstitial lung disease in...
For the first time, researchers have shown that a class of anti-fibrotic drugs slows the progression of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA).
View ArticleY chromosome loss in men can lead to deadly heart failure, research shows
The loss of the male sex chromosome as many men age causes the heart muscle to scar and can lead to deadly heart failure, new research from the University of Virginia School of Medicine shows.
View ArticlePirfenidone significantly reduces a marker of heart muscle scarring
Patients with heart failure with preserved ejection fraction who took the antifibrotic drug pirfenidone saw a significant reduction in a marker of heart muscle scarring compared with patients who...
View ArticlePowerful treatment for IPF stops dangerous scar formation in mouse lungs
A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the...
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